lasma of pregnant and preeclamptic omen activates monocytes in vitro
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چکیده
TUDY DESIGN: Blood samples were taken from patients with earlynset severe preeclampsia (n 9), healthy pregnant women (n 9), nd healthy nonpregnant women (n 9). A monocytic cell line was ncubated with the plasma for 4, 16, and 24 hours. After the incubation, eactive oxygen species (ROS) production and intercellular adhesion olecule (ICAM)-1 expression (protein and messenger ribonucleic cid) were measured.
منابع مشابه
Plasma of pregnant and preeclamptic women activates monocytes in vitro.
OBJECTIVE The objective of the study was to test the hypothesis that factors circulating in the plasma of pregnant women and women with preeclampsia activate monocytes. STUDY DESIGN Blood samples were taken from patients with early-onset severe preeclampsia (n = 9), healthy pregnant women (n = 9), and healthy nonpregnant women (n = 9). A monocytic cell line was incubated with the plasma for 4...
متن کاملPregnancy and Preeclampsia Affect Monocyte Subsets in Humans and Rats
INTRODUCTION Both nonclassical and intermediate monocytes have been implicated in different inflammatory conditions. We hypothesized that these monocytes would increase during pregnancy, a condition associated with generalized activation of inflammatory responses and that they would increase even more during preeclampsia, in which inflammatory responses are further stimulated. In the present st...
متن کاملCytokine production by monocytes, NK cells, and lymphocytes is different in preeclamptic patients as compared with normal pregnant women.
OBJECTIVE To measure cytokine production in ex vivo stimulated leukocyte populations of women with normal pregnancy and those with preeclampsia. METHODS Whole blood from preeclamptic and normal pregnant women was stimulated with LPS or PMA/Ca-ionophore. The percentages of IFN gamma and IL-2, 4, and 10 producing lymphocytes and NK cells and the percentages of TNFalpha, IL-1 beta, and IL-12 pro...
متن کاملEndogenous and Uric Acid-Induced Activation of NLRP3 Inflammasome in Pregnant Women with Preeclampsia
Preeclampsia (PE) is a specific syndrome of pregnancy, characterized by hypertension and proteinuria. This pathology is associated with hyperuricemia and elevated serum levels of inflammatory cytokines. Uric acid crystals may activate an intracellular complex called inflammasome, which is important for processing and release of inflammatory cytokines. This study investigated the state of monocy...
متن کاملEvaluation of 24-Hour Urine Copper in Preeclamptic Vs. Normotensive Pregnant and Non-Pregnant Women
Background The aim of this study was to evaluate copper status in women with preeclampsia. MaterialsAndMethods Sixty preeclamptic, sixty normotensive pregnant and sixty healthy nonpregnant women were enrolled in a cross sectional study. The 24-hour urine copper was compared among the women. Results There was significant difference in the copper concentration of 24-hour urine among the three gro...
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تاریخ انتشار 2008